What is considered a safe dose of intravenous fentanyl for an adult without opioid tolerance?

In the context of intravenous fentanyl administration for an adult without opioid tolerance, the dose of 25 micrograms is considered a safe starting point. This is mainly because fentanyl is a potent opioid analgesic, and using a conservative dose helps to minimize the risk of respiratory depression and other adverse effects, especially in individuals who are not accustomed to opioids.

Doses lower than 25 micrograms may not provide sufficient analgesia for certain procedures, while doses higher than 25 micrograms may be excessive and can lead to significant side effects in an opioid-naive patient. Intravenous fentanyl has a rapid onset of action, which also necessitates caution when determining the appropriate dose. Starting with 25 micrograms allows healthcare providers to assess the patient's response and adjust just as necessary, ensuring patient safety and comfort during the procedure.